Frances Sharom

Professor Emerita College of Biological Science Department of Molecular and Cellular Biology Guelph, Ontario fsharom@uoguelph.ca Office: (519) 824-4120 ext. 52247

Bio/Research

The research in my lab focusses on eukaryotic membrane proteins important in health and disease. The long-term goal is to understand the structure, function, and dynamics of these proteins at the molecular level, and to address their role in the normal functioning of the cell, as well as in disea...

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Bio/Research

The research in my lab focusses on eukaryotic membrane proteins important in health and disease. The long-term goal is to understand the structure, function, and dynamics of these proteins at the molecular level, and to address their role in the normal functioning of the cell, as well as in disease states, such as cancer and genetic disorders. One important approach that we take is to study the purified membrane proteins following reconstitution into phospholipid bilayer vesicles. A variety of biochemical and biophysical approaches are then used to probe the molecule under study. Techniques in current use in our lab include fluorescence spectroscopy (both extrinsic fluorescence probes covalently linked to proteins or lipids, and intrinsic protein tryptophan fluorescence); NMR spectrometry, dynamic light scattering, differential scanning calorimetry, as well as biochemical assays for transport and enzymatic activity.



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Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338

Kevin Gonsalves
kgonsalves@uoguelph.ca
519-824-4120 ext. 56982