Graham Holloway
Associate Dean Research, College of Biological Science
Professor
College of Biological Science
Department of Human Health and Nutritional Sciences
Guelph, Ontario
ghollowa@uoguelph.ca
Office:
(519) 824-4120 ext. 53688
(519) 824-4120 ext. 56654
Expert In
Bio/Research
Dr. Holloway's research focuses on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. Holloway uses a variety of te...
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Bio/Research
Dr. Holloway's research focuses on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. Holloway uses a variety of techniques to examine mitochondrial function (isolated mitochondria, permeabilized fibres, whole muscle incubations), use molecular biological approaches to up-and down-regulate mitochondrial proteins, as well exercise and aerobic training to study what regulates mitochondrial fatty acid oxidation. Holloway's lab applies this knowledge to the study human exercise performance as well as type 2 diabetes, a condition that has been speculated to have alterations in mitochondria as a key event in the progression and/or development of this disease.
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