Graham Holloway

Associate Professor College of Biological Science Department of Human Health and Nutritional Sciences Guelph, Ontario ghollowa@uoguelph.ca Office: (519) 824-4120 ext. 53688

Bio/Research

My research has been focused on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. I use a variety of techniques to...

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Bio/Research

My research has been focused on understanding the regulation of mitochondrial fatty acid oxidation (breakdown of fat yielding energy) in skeletal and cardiac muscle, which can be influenced by 1) the transport of fat into mitochondria and 2) mitochondrial content. I use a variety of techniques to examine mitochondrial function (isolated mitochondria, permeabilized fibres, whole muscle incubations), use molecular biological approaches to up-and down-regulate mitochondrial proteins, as well exercise and aerobic training to study what regulates mitochondrial fatty acid oxidation. We apply this knowledge to the study human exercise performance as well as type 2 diabetes, a condition that has been speculated to have alterations in mitochondria as a key event in the progression and/or development of this disease.



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Media Relations

Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338