Jim Kirkland

Associate Professor College of Biological Science Department of Human Health and Nutritional Sciences Guelph, Ontario jkirklan@uoguelph.ca Office: (519) 824-4120 ext. 56693

Bio/Research

Niacin is a B vitamin that is involved in energy metabolism, but it also plays key roles in DNA repair and in signal transduction. Poly(ADP-ribose) is synthesized on proteins in response to DNA damage, using nicotinamide adenine dinucleotide (NAD) as substrate. Poly(ADP-ribose) synthesis is impor...

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Bio/Research

Niacin is a B vitamin that is involved in energy metabolism, but it also plays key roles in DNA repair and in signal transduction. Poly(ADP-ribose) is synthesized on proteins in response to DNA damage, using nicotinamide adenine dinucleotide (NAD) as substrate. Poly(ADP-ribose) synthesis is important in DNA repair and we are testing the effect of niacin deficiency on poly(ADP-ribose) synthesis, DNA repair rates, apoptosis and the progression of leukemia in response to carcinogen exposure. NAD and nicotinic acid are also used to make cyclic ADP-ribose and NAADP, two molecules that control the release of calcium from intracellular stores. Calcium release controls many aspects of cell signalling, and we are intersted in the processes of long term depression and potentiation that occur in brain neurons during the development of memory and learning. We are testing the effect of niacin deficiency and pharmacological supplementation on maze learning and brain metabolism.



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Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338