Nina Jones

Associate Professor College of Biological Science Department of Molecular and Cellular Biology Guelph, Ontario jonesmcb@uoguelph.ca Office: (519) 824-4120 ext. 53643

Bio/Research

Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human disease. Signal transduction is a central process in multicellular organisms that allows for the exchange of informati...

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Bio/Research

Research in our laboratory is focused on defining eukaryotic signal transduction pathways, and investigating how mutations in components of these pathways can contribute to human disease. Signal transduction is a central process in multicellular organisms that allows for the exchange of informational cues between and within cells. These cues are interpreted by organized networks of protein interactions inside the cell which regulate complex biochemical events, ultimately converting them into biological responses such as growth, migration, differentiation and survival. Cells have evolved a tremendous ability to selectively activate specific downstream pathways, through formation of distinct protein complexes. Understanding the molecular basis of these interactions is therefore a significant challenge in biology, and it is of key importance in defining how certain mutations can lead to pathological conditions such as kidney disease and cancer. To address these questions, our research team utilizes an interdisciplinary approach, which includes modern mouse genetic tools, cell culture models, high-resolution microscopy, large-scale profiling techniques and clinical specimens.

Current areas of research include:

- Signalling pathways in kidney podocytes.

- Cell migration pathways in cardiovascular development.

- Characterization of a novel neuronal adaptor protein, ShcD.


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Media Relations

Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338