Steffen Graether

Associate Professor College of Biological Science Department of Molecular and Cellular Biology Guelph, Ontario graether@uoguelph.ca Office: (519) 824-4120 ext. 56457

Bio/Research

My enthusiasm for studying antifreeze proteins has continued as an independent investigator. These intriguing proteins are found in a number of cold-environment organisms such as fish, insects, plants and bacteria. Though the freezing point is thought to be depressed through the “Kelvin Effect”, ...

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Bio/Research

My enthusiasm for studying antifreeze proteins has continued as an independent investigator. These intriguing proteins are found in a number of cold-environment organisms such as fish, insects, plants and bacteria. Though the freezing point is thought to be depressed through the “Kelvin Effect”, it is still unclear after many years of study how the protein binds to the ice surface. Our group is interested in understanding how antifreeze protein binds to its ligand. We are studying the protein both in solution and in ice using NMR, and will test our models by measuring antifreeze activity of mutated and modified proteins.

A second project involves the study of another stress-response protein known as dehydrin. These proteins are expressed in plants during times of desiccative stress, and are thought to bind water, protect the cellular membrane from drying and prevent proteins from denaturing. Dehydrins are predicted to be “intrinsically disordered proteins” (IDPs), meaning that they do not have a defined structure as we understand it. We are using NMR to characterize the flexibility of dehydrins and understand how they function.


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Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338