Ray Lu

Photo of Ray Lu

Associate Professor Coordinator, Graduate Studies College of Biological Science Department of Molecular and Cellular Biology Guelph, Ontario rlu@uoguelph.ca Office: (519) 824-4120 ext. 53612
(519) 824-4120 ext. 56247

Bio/Research

During the course of their study of gene regulation events in virus-host cell interaction, Dr. Lu has identified three new cellular proteins, Luman/CREB3, Zhangfei/CREBZF, and Luman-recruiting factor (LRF). These proteins play key roles in animal stress responses, specifically the Unfolded Protei...

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Bio/Research

During the course of their study of gene regulation events in virus-host cell interaction, Dr. Lu has identified three new cellular proteins, Luman/CREB3, Zhangfei/CREBZF, and Luman-recruiting factor (LRF). These proteins play key roles in animal stress responses, specifically the Unfolded Protein Response (UPR) that is caused by stress in the endoplasmic reticulum. The UPR has been linked to animal development, cell differentiation, as well as a variety of human diseases such as Alzheimer’s, diabetes, cancer and viral infection. They are currently using gene knockout mouse models, combined with molecular and cellular biology techniques to study:

- Stress signalling mediated by these proteins (their upstream and downstream targets), and how it is related to cellular processes or animal diseases (lipid metabolism/obesity, hypoxia/cancer, glucose metabolism/diabetes, and inflammation). As well as the molecular mechanism of how these genes/proteins are regulated during the stress response (e.g., transcriptional regulation, protein translational modification and trafficking etc).

- Molecular Mechanisms of Aging: Another new and exciting field that they have recently undertaken is to study of the mechanisms of aging using planarians (flatworms). The planarians are potentially a better model system than traditional fruitflies and C. elegans (round worms), both of which have undergone extensive gene loss during evolution and are largely post-mitotic in their adult life. They are working to establish planarians as a new aging model to test the hypothesis that longevity requires multiplex resistance to stress. They hope to identify genes or alleles that confer such multiplex stress resistance and/or promote longevity.


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Angela Mulholland
angela.mulholland@uoguelph.ca

Kimberly Moser
kmoser@uoguelph.ca