Terry Van Raay

Assistant Professor College of Biological Science Department of Molecular and Cellular Biology Guelph, Ontario tvanraay@uoguelph.ca Office: (519) 824-4120 ext. 52864
(519) 824-4120 ext. 56496

Bio/Research

Many of the signaling pathways that are involved in development are also involved in the onset and progression of disease. As an example, the Wnt signaling pathway is required for during many stages of development and in the homeostasis of stem cells in the adult. Perturbation of this pathway in...

Click to Expand >>

Bio/Research

Many of the signaling pathways that are involved in development are also involved in the onset and progression of disease. As an example, the Wnt signaling pathway is required for during many stages of development and in the homeostasis of stem cells in the adult. Perturbation of this pathway in stem cells in the adult often leads to cancer. It is now known that about 80% of colorectal cancers are caused by mutations in the Wnt signaling pathway. As this pathway is important for both proper development and disease, I am curious to know how this pathway can turn it self on and off so many times during development and why it fails to turn off in disease.

Click to Shrink <<

Links

Media Relations

Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338