Terry Van Raay

Assistant Professor College of Biological Science Department of Molecular and Cellular Biology Guelph, Ontario tvanraay@uoguelph.ca Office: (519) 824-4120 ext. 52864
(519) 824-4120 ext. 56496

Bio/Research

Animal development proceeds through the coordinated effort of several signaling pathways that are highly conserved throughout evolution. Many of these same signaling pathways continue to regulate stem cells in the adult. As many cancers arise from stem cells, it is not surprising that the same ...

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Bio/Research

Animal development proceeds through the coordinated effort of several signaling pathways that are highly conserved throughout evolution. Many of these same signaling pathways continue to regulate stem cells in the adult. As many cancers arise from stem cells, it is not surprising that the same pathways required for development are the ones that also cause disease when they become unregulated by mutations. The Van Raay lab is interested in understanding how these signaling pathways are regulated during development with the ultimate goal of figuring out how to control the pathway in disease. Towards this end we focus on the highly conserved Wnt signaling pathway which, when misregulated, is the cause of greater than 90% of all colon cancers. We take advantage of the zebrafish model, using CRISPR technology to create genetic mutants, transgenics to visualize active signaling and cell biology and biochemistry to interrogate the molecular mechanisms that regulate this important pathway.

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Links

Media Relations

Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338

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Media Relations

Lori Bona Hunt
l.hunt@exec.uoguelph.ca
519-824-4120 ext. 53338

Deirdre Healey
healeyd@uoguelph.ca
519-824-4120 ext. 56581

Hannah James
hjames@uoguelph.ca
519-824-4120 ext. 56982

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