Dr. Coppolino's laboratory aims to elucidate the molecular mechanisms that link the activities below, allowing them to be coordinated during changes in cell adhesion and motility.
Cell adhesion and migration are fundamentally important to the existence of multicellular organisms. Disrupt...
Dr. Coppolino's laboratory aims to elucidate the molecular mechanisms that link the activities below, allowing them to be coordinated during changes in cell adhesion and motility.
Cell adhesion and migration are fundamentally important to the existence of multicellular organisms. Disruption of normal cellular adhesive and migratory activities can lead to developmental disorders and contribute to the progression of arthritis, immunological deficiencies and cancer.
Both cell adhesion and migration are complex processes involving numerous biochemical signalling events, reorganization of the cellular cytoskeleton and localized remodelling of the plasma membrane.